Sunday, April 4, 2010

Parkinson's Disease: Calcium Channel Blockers with Treatment Potential

CCBs that cross the Blood Brain Barrier for PD
Most of us read of the California-Denmark study based upon many years of data
from which it was observed that some calcium channel blockers have been found
to decrease the PD risk factor by about 27%.
 
But what about those who already have Parkinson's?
Today we'll skip the toxic dopamine argument between Mosharov and Surmeier etal
and just take an actual look at the CCBs in the Dihydropyridine class.
Specifically we show the L-type CA(2+) CCBs that can cross the blood brain barrier.  
Next we'll post the discussions, the disagreement and study links. 



DIHYDROPYRIDINE
CALCIUM
CHANNEL
BLOCKERS
Also known asNotes
Amlodipine
Norvasc
Perivasc, Istin, Agen, Aken
Amidipin, Dailyvasc, Lopin,
Amcard, Ambolet

Crosses BBB 
3rd generation
Lipophilic Dihydropyridine
May accumulate in brain
AranidipineSapresta-
AzelnipidineCalblock
Crosses BBB
scavenges hydroxyl radicals
but not superxide radicals
Reduced levels of
intercellular ROS
BarnidipineHypoCa-
BenidipineConiel
may act in a similar manner
to nimodopine
CilnidipineAtelec, Cinalong,
Siscard, Cilacar

Crosses BBB
dual blocker of L & N-type
calcium channels
does not target protein
kinase C
ClevidipineCleviprex
Crosses BBB
ultra short acting intravenous
CA2+ CB
EfonidipineLandel
Another T-type
selective CCB
some L-type inhibition
Felodipine
Plendil
Renedil (in Canada)

Crosses BBB
2nd generation    
IsradipineDynaCirc, Prescal
Crosses BBB
8 hour half-life
2nd generation
LacidipineMotens, Lacipil
Exhibits high partition
coefficients into
phosphatidycholine
LercanidipineZandip
Does not readily cross BBB
3rd generation
has a molecular design which
imparts greater solubility
within the arterial cellular
membrane bilayer,
membrane-controlled kinetics
and a high cholesterol
tolerance factor.
Mandipine
Artedil, Calslot,
Manyper, Iperten, Mandipot
Manivasc, Vascoman

3rd generation
less potential for pedal
edema than other CCBs
Nicardipine
Cardene,  Carden SR

Crosses BBB
Similar to Nifedipine
2nd generation
Nifedipine
Adalat, Procardia
Apo-Nifed (Canada)
Novo-nifedin (Canda)
Nu-nifed (Canada

Crosses BBB
Lipophilic Dihydropyridine
NilvadipineNivadilBlocks L-type channels
Nimodipine
Nimotop, NIMO
Nimodipina

Crosses BBB
similar to Nifedipine
Lipophilic Dihydropyridine
Nisoldipine
Baymycard, Sular, Syscor
-
Nitrendipine
Cardif, Baylotensin,
Baypress, Deiten,
Nidrel, Nitrepin
-
PranidipineAcalas
Carries grapefruit juice
warning as do other CCBs

DIHYDROPYRIDINE
CCBs
Known asNotes

2 comments:

  1. Calcium Antagonist Blockers or Calcium Channel Blockers (CCBs)
    The main function of a Calcium Channel Blocker is to reduce the blood pressure. They do so by disrupting the calcium conduction of calcium channels.Hence they are employed in Hypertensive emergencies when there is an urgent need to reduce the blood pressure in order to prevent or limit target organ damage.This action makes it one of the best options for usage upon people with hypertension.

    http://heart-consult.com/articles/118/why-use-calcium-antagonists

    ReplyDelete
  2. Please be advised that the link in the above comment is to a company operating in Germany and India. The information at the site is for heart patients. It may be useful for some people and so we allowed it to remain.
    Normally we do not allow commercial or commercial-type links in comments

    ReplyDelete

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