Parkinson's Disease News Updates in Brief

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From Parkinson's Action Network:

VA Secretary Supports Veterans with Parkinson's Disease Exposed to Agent Orange
Veterans Administration Establishes Presumption of Service Connection for Vietnam Veterans with PDM

Eric Shinseki, Secretary of Veterans Affairs, established that Parkinson’s disease will receive a presumption of service connection for disabled Vietnam veterans living with Parkinson’s disease.  Based on a July 2009 report by the National Academy of Science’s Institute of Medicine (IOM), this decision simplifies and accelerates the benefits application process for Vietnam veterans with Parkinson’s disease who were exposed to Agent Orange.  Now, Vietnam veterans with Parkinson’s disease applying for disability benefits do not have to prove an association between their illness and military service.

“The entire Parkinson’s disease community supports this decision by Secretary Shinseki,” said Amy Comstock Rick, PAN Chief Executive Officer.  “This will now allow our Vietnam veterans to receive the support and care they so rightly deserve rather than becoming experts on Agent Orange exposure simply to apply for benefits.”

...."available evidence supports a possible link between exposure to Agent Orange and Parkinson’s disease.  Along with Parkinson’s disease, the Secretary also established a service connection for B cell leukemias (such as hairy cell leukemia) and ischemic heart disease.  There are 12 other presumed illnesses recognized by the VA"

....."The U.S. Military Veterans with Parkinson’s (USMVP), a group of over 200 Vietnam veterans living with Parkinson’s disease, has championed this issue for years and has strongly advocated for VA benefits.  It was through their hard work and determination that Vietnam veterans exposed to Agent Orange will now receive the benefits due to them for their service."

To read more

Nutritional Supplements

Green Tea

Drinking five cups of green tea per day may reduce the incidence of psychological distress by 20 per cent, says a new study from Japan.

Green tea extracts may slow smokers’ lung damage

Omega 3

Omega-3 may prevent age-related sight loss

UKs FSA opposes omega-3 claims that would ‘mislead consumers’

Omega 6

Another viewpoint on Omega 6

CoQ10

Supplements of coenzyme Q10 (CoQ10) may protect or retard the development of fatty liver related to obesity, suggest findings from an animal study

CoQ10 by any other name:

Andelir®, CoenzymeQ, Co-enzyme Q10, Coenzyme Q (50), CoQ, CoQ10, CoQ(50), Co-Q10, CoQ-10,

2,3 dimethoxy-5 methyl-6-decaprenyl benzoquinone, Heartcin®, idebenone (synthetic analogue),

Kaneka Q10™, mitoquinone, Neuquinone®, Qunol, Q-Sorb, Q10, Q-Gel®, Solu™ Q10, Taidecanone®,

ubidecarenone, ubiquinol, ubiquinone, ubiquinone-10, ubiquinone-Q10, Udekinon®, vitamin q10, vitamin Q10

Clinical Trial: Effects of Coenzyme Q10 (CoQ) in Parkinson Disease

CoQ10 for a variety of conditions

Other News

Cogane

Cogane headed for Phase II trials
June 2010:  Phytopharm announced that it has received FDA protocol approval to procede with Cogane Phase II clinical trials. Enrollment will begin in late 2010.

You can read the Phytopharm press release here
Check back for the links to the enrollment links.

Forced Exercise

Forced Exercise Video link to Dr Jay Alberts

Reck MotoMed
ReckMotoMedWebsite

See PD Trials for contact information about the Dr Albert's Forced Exercise trial, The Therapeutic Effect of Exercise on Parkinson's disease, Study ID: 09-439

Is It True What They Say about Black Tea and PD?

Two Teas for Parkinson's disease

In recent years, I've been concentrating on my Green Tea intake because that's been the tea du jour. The ad man's darling. And certainly not without merit. Green tea has antioxidants which can possibly help PD by providing symptom relief or slowing progression. It has not been established that the green tea antioxidants are that readily available in tea form, however.

About antioxidant threatment, there isn't enough research to be definitive. There were CoQ10 studies but they have been flawed. Even the current studies are deficient because they do not include high enough doses.

There is a clinical trial now in Phase 2 in Beijing to determine if Green Tea is an effective & safe treatment for new PD patients without taking any other meds. The jury is still out and certainly the processing is important which may be why the studies are taking place in China.

We know that another constituent of tea, caffeine, is effective in delaying the onset of Parkinson's. That has already been established. And even if caffeine won't prevent PD, we're all for delaying the start time There have been caffeine studies, especially the 30+ year Hawaiian study which demonstrated a delayed onset. Tea contains more caffeine than coffee - put down that tea pot - until you brew it when it dilutes to about 2/5 less than coffee.

Green tea is made in such a way that chemically it is similar to the fresh leaf. Black tea is not a breed apart but actually the green tea leaves of the Camellia sinensis which have been completely fermented resulting in a slight reduction of caffeine and a change from the simple catechins (polyphenols) to the more complex theaflavins, theanine, an amino acid unique to tea leaves, and thearubigins.

Back in 2007 researchers in China collected data on more than 60,000 men and women in a study in which they determined that the polyphenols in green tea had an antioxidant effect which might protect neurons from the damaging effects of reactive oxygen species and nitric oxide. This has great implications for neuromotor diseases such as Parkinson's.

EGCG, Epigallocatechin Gallate, a catechin which functions as an antioxidant in green tea, converts to theaflavins and thearubigins in black teas. These can cross the the blood brain barrier and have been demonstrated to be effective against dementia in aging and AIDS related dementia plaques in a petri dish. They are now being further studied for their effectiveness in neurodegenerative diseases such as PD, AD, and HIV dementia.

What else about the black tea? Black tea is green tea which only contains about 3-10% of the polyphenols compared to 30-40% in green tea. There was a black tea study in 2008 in which it was said essentially that black tea showed an "inverse association" with Parkinson's disease risk that was not contradicted by the total caffeine intake or tobacco smoking. In other words the disease risk is actually reduced. The claim was that drinking a minimum of 23 cups of black tea a month might slow onset of PD by up to 71%

Tetley, a subsidiary of Tata Tea Ltd, is not going to be making any claims yet - they are probably still smarting over getting into hot water with the UK Advertising Standards Authority for overstating antioxidant health benefit claims.

For those of you who like milk with your cream but are concerned because you know that milk proteins could prevent the absorption of the flavonoids in your tea no worries. A Dutch study conducted a few years ago in which the total consumption was about 8 cups of tea a day. It demonstrated that the flavonoid bioavailability was not significantly affected by a bit of milk in your tea.

There's more to study about the components of green and black tea but for now, I'll enjoy my green and my black tea with milk and I think we'll be sending some black tea to our children.

Addendum 3/2012: I have read that taking mucuna puriens (the natural levodopa) with Epigallocatechin Gallate, ECGC, helps aid the transport efficiency and effectiveness.  We're ordering a green tea capsule high in EGCG to use with the curcuminoids and mucuna pruriens. We'll let you know. We'd like to lower the curcuminoid dosage as perhaps the MAOI side effects leave something to be desired.
Resources and Reading:
Green tea extracts may stop Parkinson's
Black tea may slash Parkinson's disease risk
Drinking Black Tea Reduces Risk of Parkinson's Disease
New Insights into Tea Ingredients
Theaflavins in Black Tea and Catechins in Green Tea Are Equally Effective Antioxidants
Tea Beverage
Steep it Loose
Destressing with L-theanine

A little help from Wikipedia:
Catechins
Thearubigin
Theanine